BRIEF DESCRIPTION OF THE INSTITUTION

The Institute for Biomedicine of Aging (IBA) under the direction of the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) has a long tradition on conducting research projects in the area of nutrition and aging, basic research on sarcopenia, and exercise intervention in community-dwelling older persons ranging from a healthy to a pre-frail and a frail status.

IBA is currently involved in European Projects: one project investigates determinants of diet and physical activity (DEDIPAC), in the area of physical exercise; IBA is involved in the SPRINT-T project (IMI call) – in assessing the impact of physical exercise in the prevention of frailty and sarcopenia. IBA is involved in the current EU project [2013 3201] run by the European Network for Action on Aging and Physical Activity (EUNAAPA) to disseminate and promote in medical professions the best practiced and evidence-based exercise programs and to raise awareness and increase skills in applying physical activity in older persons. IBA has also taken part in the completed international project of PROVIDE “effects of nutritional supplementation on physical performance in elderly” sponsored by the DANONE Research Institute. On national level IBA has conducted randomized trials (RCT) with exercise interventions in the area of fall prevention in the General Practitioner Setting [PreFalls NCT01032252] over a period of 24 months. In another study the effects of a power or strength intervention in pre-frail older persons was investigated [NCT00783159].

PREVIOUS EXPERIENCE RELEVANT TO THE TASKS

Both the Institute for Biomedicine of Ageing at FAU in Nürnberg as well as the Clinic of General Internal Medicine (Angiology, Diabetology, Endocrinology, Nephrology) and Geriatrics within the hospital "Barmherzige Brüder" (In English: St. John of Lord) has a long standing interest and experience in clinical management and research with (elderly) multi-morbid persons. Screening and treatment of kidney disease in elderly patients is part of routine care in the hospital as both departments - Geriatrics and Nephrology – are parts of the same clinic.

DESCRIPTION OF ANY SIGNIFICANT INFRASTRUCTURE AND/OR MAJOR ITEMS OF TECHNICAL EQUIPMENT

Besides the department of nephrology within the clinic mentioned above with an outpatient clinic and a dialysis unit, we keep close contact to many GPs working in the community within the Eastern Bavarian area. In addition, the emergency ward of our clinic is frequented by about 30,000 patients per year, among them many patients aged 75 years and above. A geriatric outpatient ward is also about to be implemented. We are therefore confident to have the necessary access to a sufficient number of eligible patients. IBA will also collaborate with Institut für Medizininformatik, Biometrie und Epidemiologie (IMBE) at FAU. Taken together, we are confident to provide suitable infrastructure both from a clinical as well as research point of view.

SHORT PROFILE OF KEY STAFF MEMBERS

Prof. Dr. med. Cornel Christian Sieber: Prof. Sieber is the Full Professor (tenure) for Internal Medicine and Geriatric Medicine at the Friedrich-Alexander-University Erlangen-Nürnberg FAU) , and the Director Institute of Biology of Aging Nürnberg, For his clinical duties, he is since April 2013 also Head of Department of Internal Medicine and Geriatrics at the “Barmherzige Brüder” Hospital, Regensburg. He serves as member in several national and international councils and association. He was president of the German Society of Geriatrics (DGG) from 2005 -2008 and president of German Society of Nutritional Medicine (DGEM) (President 2010-2012). He is Board member of the German Society of Internal Medicine, the European Union Geriatrics Medicine Societies (EUGMS) and the European Society for Clinical Nutrition and Metabolism (ESPEN). He is president of the European Academy for Medicine of Ageing (EAMA).

Priv.- Doz. Dr. Ute Hoffmann: Priv.-Doz. Dr. Hoffmann is lecturer for Nephrology and Internal Medicine at the University of Regensburg. Since February 2011, she is Head of the Department of Nephrology, which is integrated in the Department of Internal Medicine and Geriatrics at the “Barmherzige Brüder” Hospital, Regensburg. Her scientific main focus at the University of Regensburg was the research of diagnostic and prognostic parameters in human and experimental renal transplantation. During the last two years, she has established a nephro-geriatric database at the “Barmherzige Brüder” Hospital. For this project, she is actually supervising 6 postgraduates

Dr. Christian Weingart: Dr. Christian Weingart is fellow of Internal Medicine, Nephrology and Intensive Care Medicine. He completed his training in Internal Medicine Intensive Care Medicine and Nephrology at the University of Regensburg between 2004 and 2011. Since 2013 he is senior physician in Nephrology at the Department of Internal Medicine and Geriatrics at the “Barmherzige Brüder” Hospital, Regensburg. His scientific focus at the University of Regensburg was organ replacement, coagulation and platelet function in renal transplantation and patients on ECMO. Now he works with Dr. Hoffmann on the geronto-nephrologic database.

Prof. Wolfgang Uter: He as biostatistician, Deputy Directorof the Institut für Medizininformatik, Biometrie und Epidemiologie (IMBE). 

LIST OF THE FIVE MOST RELEVANT PUBLICATIONS AND/OR PRODUCTS, SERVICES, OR OTHER ACHIEVEMENTS

  1. Kiesswetter E, Pohlhausen S, Uhlig K, Diekmann R, Lesser S, Uter W, Heseker H, Stehle P, Sieber CC, Volkert D. Prognostic differences of the Mini Nutritional Assessment short form and long form in relation to 1-year functional decline and mortality in community-dwelling older adults receiving home care. J Am Geriatr Soc. 2014 Mar;62(3):512-7. doi: 10.1111/jgs.12683. Epub 2014 Mar 10.
  2. Hoffmann U, Bergler T, Rihm M, Pace C, Krüger B, Jung B, Reinhold SW, Farkas S, Rümmele P, Krämer BK, Banas B. Impact of Toll-like receptor 2 expression in renal allograft rejection. Nephrol Dial Transplant. 2011;26:1080-7.
  3. Hoffmann U, Bergler T, Rihm M, Pace C, Krüger B, Rümmele P, Stoelcker B, Banas B, Männel DN, Krämer BK. Upregulation of TNF receptor type 2 in human and experimental renal allograft rejection. Am J Transplant 2009;9:675-86.
  4. Weingart C, Lubnow M, Philipp A, Bein T, Camboni D, Müller T. Comparison of coagulation parameters, anticoagulation and need of transfusion in patients on Interventional Lung Assist and veno-venous ECMO. (submitted).