BRIEF DESCRIPTION OF THE INSTITUTION

The Medical University of Graz (MUG) comprises 40 clinical and non-clinical institutions. It is closely associated with Graz University Hospital, which is amongst the largest Hospitals in Europe (more than 2.000 beds) and is a top quality institution offering all fields of human medicine. Subsequently, Graz University Hospital is the flagship Hospital of the Steiermärkische Krankenanstalten Ges.m.b.H. which manages 22 Hospitals in Styria. Prof. Gerhard Wirnsberger is a well experienced nephrologist and geriatrician, who has established nephrogeriatrics at the Department of Internal Medicine since 3 years. His research focus is on chronic kidney disease related to aging. By that he is an outspoken expert in urinary cytology as well as laboratory standardizing procedures to evaluate kidney function. He is also active member of an expert group between EUGMS and ERA/EDTA working out clinical recommendations on chronic kidney disease in old age. The Division of nephrology works in close contact to Geriatrics. Main focus in research of Geriatrics is management of geriatric syndromes and frailty in old age as assessed in comprehensive geriatric assessment. Prof. Roller-Wirnsberger is also member of the EIP Action Group A3, collaborating in a Pan- European consortium on “frailty and nutrition”.

Furthermore, she is actively involved in educational programme development in adult education in under and postgraduate education on university as well as European level. The Graz group provides high level of experience in trans-disciplinary patient centred care programs. 

PREVIOUS EXPERIENCE RELEVANT TO THE TASKS

Previously run project highlighted the sensitivity and specificity of different laboratory tests to assess kidney function in various sets of populations and age ranges. 3 currently ongoing projects highlight the impact of impaired kidney function (CKD) on functional capacity of patients also including changes in individual functional patterns in end stage CKD while being listed for autologous organ transplantation and during chronic hemodialysis programs

DESCRIPTION OF ANY SIGNIFICANT INFRASTRUCTURE AND/OR MAJOR ITEMS OF TECHNICAL EQUIPMENT

The Medical university of Graz provides infrastructure of hospital setting treating approximately 1400 patients at the Division of Nephrology/ Department of Internal Medicine being hospitalized and 15.000 patients/ year on outpatient basis. The Division of Nephrology furthermore holds a urinary analysis laboratory and possible access to any technical equipment in research. MUG hosts the largest biobank within Europe.

SHORT PROFILE OF KEY STAFF MEMBERS

Prof. Gerhard Wirnsberger, MD: 11.08.1957, Klagenfurt/ Austria. Specialist in Pathology, Internal Medicine, Nephrology, Geriatrics Consultant and Head of Nephrogeriatrics, Medical University of Graz, Austria since 2012 Member of The Austrian Society of Geriatrics, Nephrology and Internal Medicine Member of the American Society of Pathology and Laboratory Medicine Expert within the Expert panel on Chronic Kidney Disease and Functional Decline of ERA/EDTA and EUGMS Special Degree on Quality Assurance and Risk Management.

Prof. Regina Roller-Wirnsberger, MD, MME: 21. 04 1965, Cairo/ Egypt Professor for Geriatrics Medicine and Competence based Curricular Development President of the Austrian Society of Geriatrics and Gerontology Secretary and Executive Board Member of the European Union Geriatrics Medicine Society (EUGMS) Vice President of the European Academy of Aging (EAMA) Executive Board Member of the Austrian Platform on Interdisciplinary Aging Research (ÖPIA) Executive Board Member of the Austrian Society on Nutrition (AKE) Partner in the European Innovation Partnership (EIP) in A3 Action Group (Frailty and Functional Decline).

 

LIST OF THE FIVE MOST RELEVANT PUBLICATIONS AND/OR PRODUCTS, SERVICES, OR OTHER ACHIEVEMENTS

  1. Wagner D, Adunka C, Kniepeiss D, Jakoby E, Schaffellner S, Kandlbauer M, Fahrleitner-Pammer A, Roller RE, Kornprat P, Müller H, Iberer F, Tscheliessnigg KH, Serum albumin, subjective global assessment, body mass index and the bioimpedance analysis in the assessment of malnutrition in patients up to 15 years after liver transplantation. Clin Transplant. 2011 Jul-Aug;25(4):E396-400
  2. Kniepeiss D, Wagner D, Wirnsberger G, Roller RE, Wasler A, Iberer F, Tscheliessnigg KH. Serum cystatin C is an easy to obtain biomarker for the onset of renal impairment in heart transplant recipients. J Thorac Cardiovasc Surg. 2010;140(3):688-693
  3. Kniepeiss D, Stiegler P, Roller RE, Groselj-Strele A, Wirnsberger G. Cystatin C has prognostic value after liver transplantation. Nat Clin Pract Nephrol. 2008;4(3):E1
  4. Wagner D, Kniepeiss D, Stiegler P, Zitta S, Bradatsch A, Robatscher M, Müller H, Meinitzer A, Fahrleitner-Pammer A, Wirnsberger G, Iberer F, Tscheliessnigg K, Reibnegger G, Rosenkranz AR. The assessment of GFR after orthotopic liver transplantation using cystatin C and creatinine-based equations. Transpl Int. 2012;25(5):527-536
  5. Fahrleitner-Pammer A, Herberth J, Browning SR, Obermayer-Pietsch B, Wirnsberger G, Holzer H, Dobnig H, Malluche HH. Bone markers predict cardiovascular events in chronic kidney disease. J Bone Miner Res. 2008;23(11):1850-1858